| Item Type | Name |
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Concept
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Cross-Sectional Studies
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Concept
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Mice, Inbred C3H
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Concept
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Models, Chemical
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Concept
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Mice, Inbred Strains
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Concept
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Models, Molecular
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Concept
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Mice, Inbred CBA
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Concept
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Mice, Transgenic
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Concept
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Mice, Inbred C57BL
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Concept
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Cohort Studies
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Concept
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Linear Models
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Concept
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Mice, Inbred DBA
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Concept
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Case-Control Studies
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Concept
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Mice, Obese
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Concept
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Mice, Knockout
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Concept
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Models, Immunological
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Concept
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Cross-Over Studies
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Concept
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Genetic Association Studies
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Concept
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Mice
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Concept
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Models, Statistical
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Concept
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Logistic Models
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Concept
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Mice, 129 Strain
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Concept
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National Heart, Lung, and Blood Institute (U.S.)
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Concept
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Disease Models, Animal
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Concept
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Follow-Up Studies
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Concept
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Models, Biological
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Concept
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Prospective Studies
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Concept
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Retrospective Studies
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Concept
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Mice, Inbred NOD
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Academic Article
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Glucose-regulated translational control of proinsulin biosynthesis with that of the proinsulin endopeptidases PC2 and PC3 in the insulin-producing MIN6 cell line.
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Academic Article
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Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells.
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Academic Article
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Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins.
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Academic Article
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Insulin-secreting non-islet cells are resistant to autoimmune destruction.
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Academic Article
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The ratio of mouse insulin I:insulin II does not reflect that of the corresponding preproinsulin mRNAs.
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Academic Article
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Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells).
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Academic Article
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Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis.
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Academic Article
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Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes?
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Academic Article
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Insulin secretory deficiency and glucose intolerance in Rab3A null mice.
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Academic Article
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Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells.
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Academic Article
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Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide.
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Academic Article
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Syncollin inhibits regulated corticotropin secretion from AtT-20 cells through a reduction in the secretory vesicle population.
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Academic Article
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A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli.
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Academic Article
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Insulin receptor substrate 2 plays diverse cell-specific roles in the regulation of glucose transport.
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Academic Article
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Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation.
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Academic Article
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Inositol (1,4,5)-trisphosphate dynamics and intracellular calcium oscillations in pancreatic beta-cells.
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Academic Article
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Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?
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Academic Article
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Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine beta-cells.
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Academic Article
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Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell.
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Academic Article
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Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding.
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Academic Article
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Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.
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Academic Article
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Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death.
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Academic Article
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Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents.
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Academic Article
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Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance.
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Academic Article
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Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3ß independent of JNK activation.
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Academic Article
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Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway.
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Academic Article
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How does type 1 diabetes develop?: the notion of homicide or ß-cell suicide revisited.
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Academic Article
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2-5A-dependent endoribonuclease activity and effects of A2'p5'A2'p5'A (2-5A core) in mouse pancreatic islets.
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Academic Article
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FoxO feedback control of basal IRS-2 expression in pancreatic ß-cells is distinct from that in hepatocytes.
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Academic Article
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A Kex2-related endopeptidase activity present in rat liver specifically processes the insulin proreceptor.
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Academic Article
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PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells.
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Academic Article
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Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts.
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Academic Article
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Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet ß-cells.
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Academic Article
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Long-term biochemical changes in the islets of Langerhans in mice following infection with encephalomyocarditis virus.
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Academic Article
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Molecular insights into insulin action and secretion.
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Academic Article
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Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion.
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Academic Article
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The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species.
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Academic Article
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Effect of interferon and double-stranded RNA on B-cell function in mouse islets of Langerhans.
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Academic Article
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Guidelines for the use and interpretation of assays for monitoring autophagy.
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Academic Article
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Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation.
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Academic Article
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Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus.
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Academic Article
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Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells.
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Academic Article
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A potential role for hypothalamomedullary POMC projections in leptin-induced suppression of food intake.
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Academic Article
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Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdala.
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Academic Article
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ß1 integrin is a crucial regulator of pancreatic ß-cell expansion.
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Academic Article
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Islet autoantigens: structure, function, localization, and regulation.
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Academic Article
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Direct autocrine action of insulin on ß-cells: does it make physiological sense?
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Academic Article
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Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neurons.
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Academic Article
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Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension.
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Academic Article
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Pancreatic ß-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function.
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Academic Article
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RNA Sequencing Analysis Detection of a Novel Pathway of Endothelial Dysfunction in Pulmonary Arterial Hypertension.
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Academic Article
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SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed ß cells.
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Academic Article
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In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and Its Target Slug.
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Academic Article
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The Brain-to-Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions.
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Academic Article
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Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance.
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Academic Article
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Control of food intake and energy expenditure by Nos1 neurons of the paraventricular hypothalamus.
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Academic Article
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Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats.
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Academic Article
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Codependence of Bone Morphogenetic Protein Receptor 2 and Transforming Growth Factor-ß in Elastic Fiber Assembly and Its Perturbation in Pulmonary Arterial Hypertension.
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Academic Article
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Ca(2+)-regulated serine protease associated with the nuclear scaffold.
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Academic Article
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The c-propeptide of type II procollagen binds to the enhancer region of the type II procollagen gene and regulates its transcription.
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Academic Article
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Epidemiology of communicable disease in small populations.
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Academic Article
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BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFß-TAK1-MAPK pathways in PAH.
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Academic Article
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Rabies and canine distemper virus epidemics in the red fox population of northern Italy (2006-2010).
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Academic Article
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Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits.
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Academic Article
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Reduced plasma levels of small HDL particles transporting fibrinolytic proteins in pulmonary arterial hypertension.
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Academic Article
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An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28.
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Academic Article
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Spatial organization of EphA2 at the cell-cell interface modulates trans-endocytosis of ephrinA1.
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Academic Article
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Muonium--the second radioisotope of hydrogen: a remarkable and unique radiotracer in the chemical, materials, biological and environmental sciences.
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Academic Article
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Modelling the influence of foot-and-mouth disease vaccine antigen stability and dose on the bovine immune response.
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Academic Article
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Expansion of the Knockdown Resistance Frequency Map for Human Head Lice (Phthiraptera: Pediculidae) in the United States Using Quantitative Sequencing.
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Academic Article
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Essential Role for Hypothalamic Calcitonin Receptor?Expressing Neurons in the Control of Food Intake by Leptin.
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Academic Article
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Epidemic thresholds and vaccination in a lattice model of disease spread.
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Academic Article
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A determination of antioxidant efficiencies using ESR and computational methods.
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Academic Article
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Multicomponent spectroscopic investigations of salivary antioxidant consumption by an oral rinse preparation containing the stable free radical species chlorine dioxide (ClO2.).
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Academic Article
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The Fukushima Daiichi nuclear accident.
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Academic Article
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Evolutionary entropy determines invasion success in emergent epidemics.
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Academic Article
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Novel catalysts for water splitting and green chemistry applications.
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Academic Article
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The effect of superspreading on epidemic outbreak size distributions.
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Academic Article
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Why drugs fail in clinical trials in pulmonary arterial hypertension, and strategies to succeed in the future.
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Academic Article
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Nonalcoholic steatohepatitis severity is defined by a failure in compensatory antioxidant capacity in the setting of mitochondrial dysfunction.
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Academic Article
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Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study.
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Academic Article
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Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity.
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Academic Article
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Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1.
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Academic Article
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Identification of the Novel Tooth-Specific Transcription Factor AmeloD.
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Academic Article
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Iron deficiency in pulmonary arterial hypertension: a potential therapeutic target.
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Academic Article
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On the critical behaviour of simple epidemics.
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Academic Article
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Variational data assimilation with epidemic models.
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Academic Article
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Contact rate calculation for a basic epidemic model.
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Academic Article
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Reduced microRNA-150 is associated with poor survival in pulmonary arterial hypertension.
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Academic Article
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US withdrawal from the COP21 Paris Climate Change Agreement, and its possible implications.
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Academic Article
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miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia.
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Academic Article
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Association of synovial inflammation and inflammatory mediators with glenohumeral rotator cuff pathology.
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Academic Article
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Identification of rare sequence variation underlying heritable pulmonary arterial hypertension.
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Academic Article
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Nicotine drives neutrophil extracellular traps formation and accelerates collagen-induced arthritis.
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Academic Article
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Pancreatic ß-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes.
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Academic Article
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The influence of viral infection on a plankton ecosystem undergoing nutrient enrichment.
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Academic Article
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Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.
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Academic Article
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Metabolic pathways associated with right ventricular adaptation to pulmonary hypertension: 3D analysis of cardiac magnetic resonance imaging.
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Academic Article
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The ADAMTS13-VWF axis is dysregulated in chronic thromboembolic pulmonary hypertension.
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Academic Article
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Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension: a UK cohort study analysis.
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Academic Article
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Combined loss of GLP-1R and Y2R does not alter progression of high-fat diet-induced obesity or response to RYGB surgery in mice.
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Academic Article
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Proteomic Analysis of Restored Insulin Production and Trafficking in Obese Diabetic Mouse Pancreatic Islets Following Euglycemia.
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Academic Article
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Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension.
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Academic Article
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Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension.
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Academic Article
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Mendelian randomisation analysis of red cell distribution width in pulmonary arterial hypertension.
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Academic Article
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Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding.
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Academic Article
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Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension.
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Academic Article
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Leptin receptor-expressing nucleus tractus solitarius neurons suppress food intake independently of GLP1 in mice.
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Academic Article
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The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti.
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Academic Article
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Characterization of Signaling Pathways Associated with Pancreatic ß-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice.
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Academic Article
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A fluorescent timer reporter enables sorting of insulin secretory granules by age.
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Academic Article
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Whole-Blood RNA Profiles Associated with Pulmonary Arterial Hypertension and Clinical Outcome.
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Academic Article
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Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis.
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Academic Article
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Expression Quantitative Trait Locus Mapping in Pulmonary Arterial Hypertension.
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Academic Article
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Characterization of Signaling Pathways Associated with Pancreatic ß-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice.
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Academic Article
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Supplementation with Iron in Pulmonary Arterial Hypertension. Two Randomized Crossover Trials.
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Academic Article
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A genetic map of the mouse dorsal vagal complex and its role in obesity.
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Academic Article
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NHLBI-CMREF Workshop Report on Pulmonary Vascular Disease Classification: JACC State-of-the-Art Review.
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Academic Article
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A diagnostic miRNA signature for pulmonary arterial hypertension using a consensus machine learning approach.
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Academic Article
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NTS Prlh overcomes orexigenic stimuli and ameliorates dietary and genetic forms of obesity.
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Academic Article
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Peptide-YY3-36/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic ß-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries.
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Academic Article
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BAd-CRISPR: Inducible gene knockout in interscapular brown adipose tissue of adult mice.
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Academic Article
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Using the Plasma Proteome for Risk Stratifying Patients with Pulmonary Arterial Hypertension.
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Academic Article
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Transcriptional heterogeneity of ventricular zone cells in the ganglionic eminences of the mouse forebrain.
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Academic Article
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Autoimmunity Is a Significant Feature of Idiopathic Pulmonary Arterial Hypertension.
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Academic Article
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Local Joint inflammation and histone citrullination in a murine model of the transition from preclinical autoimmunity to inflammatory arthritis.
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Academic Article
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Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life.
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Academic Article
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PTPN1 Deficiency Modulates BMPR2 Signaling and Induces Endothelial Dysfunction in Pulmonary Arterial Hypertension.
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Academic Article
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High Plasma Levels of Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Inflammation and Cardiometabolic Risk Profiles in Pediatric Overweight and Obesity.
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Concept
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Clinical Studies as Topic
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Grant
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Mitogenic Signal Transduction in Pancreatic Beta-Cells
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Grant
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Metabolic Control of Insulin Exocytosis
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Grant
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Central Control of Pancreatic Islet Function
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Grant
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Western Region Islet Study Group
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Grant
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Metabolic Control of Proinsulin Biosynthesis Translation
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Grant
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Metabolic Control of Proinsulin Biosynthesis Translation
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Academic Article
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Restoring polyamine levels by supplementation of spermidine modulates hepatic immune landscape in murine model of NASH.
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Academic Article
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SOX17 Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension.
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Academic Article
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Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension.
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Academic Article
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Mendelian Randomization Study With Clinical Follow-Up Links Metabolites to Risk and Severity of Pulmonary Arterial Hypertension.
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